Specify the number of gene set permutations. Introduce the number of detailed GO enrichment plots we would like to create. Choose the Gene Ontology categories you want to use. Set a maximum and minimum size of the gene-sets (GOs) to be included in the ana

Using ToppGene, we performed functional analysis including Gene ontology (GO) and cytoband analysis. The false discovery rate (FDR) <0.05 and FDR <1.0 were considered to be significantly enriched for GO analysis and cytoband analysis, respectively.

For each gene, ToppGene considers all associated articles (represented as PMIDs) as literature annotation of this gene. The gene to PMID association file ("gene2pubmed.gz") was downloaded from NCBI Entrez Gene ftp site [ 18 ]. 44806 PMIDs were a