The most common side effects of Azzalure® in the glabellar lines are headache and injection site reactions (e.g. redness, swelling, irritation, rash, itching, numbness, pain, discomfort, stinging, brushing and bleeding) and for lateral canthal ines; head

Section 2: R emoval of reference to LD50. Section 4.8: Update to safety ADR section for the Glabellar Lines indication (change the frequency category for eye movement disorder from “uncommon” to “rare”) Section 10: Updated date of revision

The recommended dose is 50 Speywood units of Azzalure to be divided into 5 injection sites, 10 Speywood units are to be administered intramuscularly, at right angles to the skin, into each of the 5 sites: 2 injections into each corrugator muscle and one i