Extramammary Paget's Disease - Pathology mini tutorial

When Paget's disease occurs in sites other than breast it is called extramammary Paget's disease. Sites include vulva, perianal, scrotum, perineum, eyelid, axilla and ear. The Paget cells arise from eccrine of hair follicles and extend into the epidermis. The immunoprofile is CK7, CEA and GCDFP-15 positive with CK20 negative. Paget cells often are vacuolated containing mucin that stains magenta with PAS.
0:22 Origin of extramammary Paget's
0:53 Image of extramammary Paget's arising from eccrine glands
1:22 Sites for extramammary paget's
1:40 Differential diagnosis
1:58 Clinical presentation
2:10 Histology description of extramammary Paget's disease
2:40 Immuno for extramammary Paget's disease
3:25 Histology of vulval extramammary Paget's disease
3:46 PAS stain for mucin in tumour cells in extramammary Paget's disease