This chapter provides guidance on the evaluation of randomized controlled trial (RCT) of complex interventions. Trials are often divided into those that are explanatory and measure efficacy or pragmatic and measure effectiveness, whereas in reality they l

when transposing the results of a randomised controlled trial (RCT) to clinical practice. Here, we give some keys to assess the reliability and understand the results of such trials. Because of the wide-ranging fields of medical literature, we focus on t

to critically appraise randomized controlled trials in order to prevent such biases misleading clinical decisions. Using the three steps outlined by the Critical Appraisal